File:MOC fibers and the cholinergic synapse onto OHCs in the mature Organ of Corti-A.svg
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MOC_fibers_and_the_cholinergic_synapse_onto_OHCs_in_the_mature_Organ_of_Corti-A.svg (SVG file, nominally 1,411 × 950 pixels, file size: 8.73 MB)
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English: Schematics Showing the Central Origin (A) and Peripheral Projections (B) of the MOC Fibers and the Cholinergic Synapse onto OHCs in the Mature Organ of Corti (C) MOC efferent neurons are located in the superior olivary complex of the brainstem and project to the cochlea, where they make direct synaptic contacts at the base of the OHCs. At this synapse, ACh is released. It binds to α9α10 receptors present at the OHCs, leading to Ca2+ influx and the subsequent activation of Ca2+-dependent SK2 K+ channels and hair cell hyperpolarization. The black arrow in (A) indicates the place of electrical stimulation to activate the MOC fibers. The white arrow in (B) indicates the afferent fibers that bring the information from the IHCs to the central nervous system, and the red arrow indicates the MOC fibers. For approximately 10 d after birth (before the onset of hearing), cholinergic efferents temporarily synapse directly with IHCs (not shown in the figure) and provide a useful experimental target for the study of altered α9α10 receptors.
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2009-02-15 03:58 (UTC) |
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see below |
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This is a retouched picture, which means that it has been digitally altered from its original version. Modifications: Isolated subfigure A & converted to png. The original can be viewed here: MOC_fibers_and_the_cholinergic_synapse_onto_OHCs_in_the_mature_Organ_of_Corti.jpg. Modifications made by Mike.lifeguard. |
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[edit] Original upload log
This image is a derivative work of the following images:
- File:MOC_fibers_and_the_cholinergic_synapse_onto_OHCs_in_the_mature_Organ_of_Corti.jpg licensed with Cc-by-2.5, Cc-by-2.5/en
- 2009-02-12T23:15:32Z Mike.lifeguard 2076x525 (113339 Bytes) {{Information |Description={{en|1=Schematics Showing the Central Origin (A) and Peripheral Projections (B) of the MOC Fibers and the Cholinergic Synapse onto OHCs in the Mature Organ of Corti (C) MOC efferent neurons are loc
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This is a retouched picture, which means that it has been digitally altered from its original version. Modifications: Vectorized. The original can be viewed here: MOC_fibers_and_the_cholinergic_synapse_onto_OHCs_in_the_mature_Organ_of_Corti-A.png. Modifications made by Mike.lifeguard. |
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[edit] Original upload log
This image is a derivative work of the following images:
- File:MOC_fibers_and_the_cholinergic_synapse_onto_OHCs_in_the_mature_Organ_of_Corti-A.png licensed with Cc-by-2.5, Cc-by-2.5/en
- 2009-02-15T03:22:05Z Mike.lifeguard 670x515 (161485 Bytes) {{Information |Description={{en|1=Schematics Showing the Central Origin (A) and Peripheral Projections (B) of the MOC Fibers and the Cholinergic Synapse onto OHCs in the Mature Organ of Corti (C) MOC efferent neurons are loc
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 04:02, 15 February 2009 | | 1,411×950 (8.73 MB) | Mike.lifeguard (Talk | contribs) | ({{Information |Description={{en|1=Schematics Showing the Central Origin (A) and Peripheral Projections (B) of the MOC Fibers and the Cholinergic Synapse onto OHCs in the Mature Organ of Corti (C) MOC efferent neurons are located in the superior olivary c) |
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