File:Nodal signaling.jpg
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Summary[edit]
DescriptionNodal signaling.jpg |
English: Description of the Nodal signaling pathway. |
Date | |
Source | Own work |
Author | Sofia mr007 |
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Public domainPublic domainfalsefalse |
I, the copyright holder of this work, release this work into the public domain. This applies worldwide. In some countries this may not be legally possible; if so: I grant anyone the right to use this work for any purpose, without any conditions, unless such conditions are required by law. |
Annotations InfoField | This image is annotated: View the annotations at Commons |
Ectodermin, PPM1A, XFDR and Tgf1 negative regulate the pathway by competing with Smad components or transcription factors.
The protein expression levels of Nodal and Lefty are affected due to the activity of the miR-430 super-family.
The interaction of Nodal with BMPs (BMP3, BMP7), Lefty or with Cerberus in the outside of the cells affects its capability to bind to the receptors and reactivate the signal.
Once the protein is translated, it has to be processed in the extracellular space by Convertases (Furin and PACE4). Mature Nodal binds to the Activin receptors I and II and the co-rreceptor Cripto/Cryptic and phosphorilates Smad2 /3.
Phospho-Smad2 /3 form a complex with Smad4 and enter into the nucleus.
Dapper2 targets the Activin Receptor Type I for lysosomal degradation
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current | 04:51, 5 April 2010 | 1,168 × 1,198 (537 KB) | Sofia mr007 (talk | contribs) | {{Information |Description={{en|1=Description of the Nodal signaling pathway.}} |Source={{own}} |Author=Sofia mr007 |Date=2010-04-04 |Permission= |other_versions= }} Category:Biology Category:Developmental biology [[Category: |
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