File:Paracetamol metabolism.svg

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Paracetamol_metabolism.svg‎ (SVG file, nominally 385 × 385 pixels, file size: 185 KB)

[edit] Summary

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Description

English: Simplified schematic of the key pathways of paracetamol metabolism in the human body. The first step in conversion of paracetamol to NAPQI has been omitted for clarity.
Set in Myriad Pro.

Legend

Pathways to non-toxic metabolites

Pathway to toxic metabolites (CYP-mediated)

Detoxification pathway

Abbreviations

GlcA, glucuronic acid; GSH, glutathione; NAPQI, N-acetyl-p-benzoquinone imine.

Português: Esquema simplificado das principais vias de biotransformação do paracetamol em humanos. Para maior clareza, omitiu-se a primeira etapa da conversão do paracetamol à N-acetil-benzoquinoneimina.
Diagrama composto em Myriad Pro.

Legenda

Vias de conversão a metabólitos atóxicos

Via de conversão a metabólitos tóxicos (mediada pelo sistema P450)

Via de detoxificação

Abreviações

GlcA, ácido glicurônico; GSH, glutationa; NAPQI, N-acetil-benzoquinoneimina.

This vector image was created with Inkscape.

Date

18 January 2009(2009-01-18)

Source

Own work, after Henry, John (1995). “Poisoning”, in Marshall, William Leonard. Clinical biochemistry: metabolic and clinical aspects, p. 666, Edinburgh: Churchill Livingstone, ISBN 9780443043413; and Hendrickson, Robert G.; Kenneth E. Bizovi (2006). “Acetaminophen”, in Nelson, Lewis H.; Flomenbaum, Neal; Goldfrank, Lewis R. et al. Goldfrank's toxicologic emergencies, p. 525, New York: McGraw-Hill, ISBN 9780071437639. Both retrieved on January 18, 2009 through Google Book Search.

Author

Fvasconcellos (talk · contributions)

Permission
(Reusing this image)

I, the copyright holder of this work, hereby release it into the public domain. This applies worldwide.

In case this is not legally possible:
I grant anyone the right to use this work for any purpose, without any conditions, unless such conditions are required by law.

Other versions

File:Paracetamol metabolism.png (English, also simpified)
File:Métabolisme paracetamol.png (French, also simplified)
File:Metabolizm paracetamolu.svg (more detailed, Polish)

File history

Click on a date/time to view the file as it appeared at that time.

	Date/Time	Thumbnail	Dimensions	User	Comment
current	13:13, 19 January 2009		385×385 (185 KB)	Fvasconcellos (talk \| contribs)	(fixed NAPQI structure)
	17:47, 18 January 2009		385×385 (185 KB)	Fvasconcellos (talk \| contribs)	(alignment)
	16:15, 18 January 2009		385×385 (191 KB)	Fvasconcellos (talk \| contribs)	(== Summary == {{validSVG}} {{Information \|Description= {{en\|Simplified schematic of the key pathways of {{w\|paracetamol}} metabolism in the human body. The first step in conversion of paracetamol to NAPQI has been omitted for clari)