File:PiRNA pathway is required for spermatogenesis in mouse..jpg

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English: A. High levels of apoptosis in miwi-/- testes, as judged by the TUNEL (red) labeling. Scale bar is 25μM. B. Spermatogenesis arrest in miwi-/- at the early round spermatid stage. Hematoxylin/Eosin staining of miwi+/- and miwi-/- testes show the absence of elongated spermatid (e) in miwi-/- and the presence of fragmented nuclei (arrows). Stages of spermatogenesis labeled here- spermatogonia (sg), spermatocytes (sc), round spermatid (r). Scale bar is 25 μM. Panels A and B reprinted from Deng and Lin (2002) with permission from Elsevier. C. Increased DNA damage accumulation in miwi2-/- testis. Intense staining of γ-H2AX (brown) and presence of abnormal spermatocytes (AS) in seminiferous tubules from 14 day old miwi2-/- animals. Zygotene cells (z) are marked in the miwi2+/- and absent in the miwi2-/- null mice. Reprinted from Carmell et al. (2007), with permission from Elsevier.
Date Published July 30, 2008.
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StemBook Figure 3 piRNA pathway is required for spermatogenesis in mouse.

  • Khurana, J.S. and Theurkauf, W.E., piRNA function in germline development (July 30, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.12.1, http://www.stembook.org.
Author Khurana, J.S. and Theurkauf, W.E., piRNA function in germline development (July 30, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.12.1, http://www.stembook.org.
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