File:Progressive transformation of germinal centers -2- intermed mag.jpg

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Description
English: Intermediate magnification micrograph of progressive transformation of germinal centres, abbreviated PTGCs and also progressive transformation of germinal centers, in an excisional lymph node biopsy. H&E stain.

PTGCs is a reactive process of undetermined etiology, that is usually characterized clinically by localized lymphadenopathy and is typically asymptomatic. It may occasionally recur and in a small proportion of patients has been reported to subsequently develop Hodgkin lymphoma (usually nodular lymphocyte predominant Hodgkin lymphoma).[1][2]

Features:

  • Follicular hyperplasia (many follicles).
  • Focally large germinal centers with:
    • Poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes) -- key feature.[3]
    • Expanded mantle zone.

References

  1. ↑ Hansmann ML, Fellbaum C, Hui PK, Moubayed P (February 1990). "Progressive transformation of germinal centers with and without association to Hodgkin's disease". Am. J. Clin. Pathol. 93 (2): 219–26. PMID 2405631.
  2. ↑ Kojima M, Nakamura S, Motoori T, et al. (April 2003). "Progressive transformation of germinal centers: a clinicopathological study of 42 Japanese patients". Int. J. Surg. Pathol. 11 (2): 101–7. PMID 12754626.
  3. ↑ Verma A, Stock W, Norohna S, Shah R, Bradlow B, Platanias LC (2002). "Progressive transformation of germinal centers. Report of 2 cases and review of the literature". Acta Haematol. 108 (1): 33–8. PMID 12145465.

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Author Nephron

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