File:Protease mechanisms summary.png
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Summary[edit]
| Description |
English: A comparison of the two mechanisms used for proteolysis. enzyme is shown in black, substrate protein in red and water in blue.The top panel shows 1-step hydrolysis where the enzyme uses an acid to polarise water which then hydrolyses the substrate. The bottom panel shows 2-step hydrolysis where a residue within the enzyme is activated to act as a nucleophile (Nu) and attack the substrate. This forms an intermediate where the enzyme is covalently linked to the N-terminal half of the substrate. In a second step, water is activated to hydrolyse this intermediate and complete catalysis. Other enzyme residues (not shown) donate and accept hydrogens and electrostatically stabilise charge build-up along the reaction mechanism. |
| Date | |
| Source | Own work |
| Author | Thomas Shafee |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 00:39, 24 November 2013 | | 2,302 × 1,281 (150 KB) | Evolution and evolvability (talk | contribs) | text formatting |
| 00:29, 24 November 2013 |  | 2,302 × 1,457 (178 KB) | Evolution and evolvability (talk | contribs) | User created page with UploadWizard |
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