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Santa Cruz may refer to
- a city in Tenerife, Canary Island, Spain: Santa Cruz de Tenerife
- a city in California, USA: Santa Cruz, California
- the capital city of the Canary Island La Palma: Santa Cruz de La Palma
- a municipality in the Honduran department of Lempira: Santa Cruz, Lempira
- a municipality of the Brasilian state Paraíba: Category:Santa Cruz (Paraíba)
- a province in Argentina: Category:Santa Cruz Province
- a group of islands in the Salomons, see Category:Santa Cruz Islands
- the main island of the Santa Cruz Islands, see Category:Nendo Island
- Santa Cruz (Galápagos), one of the Galapágos Islands, Ecuador
- a 1st level subdivision (departamento) of Bolivia: Category:Santa_Cruz,_Bolivia also is the abbreviated name of the main city of Santa Cruz, Santa Cruz de la Sierra
- a Finnish hard rock band, see Category:Santa Cruz (band)
Santa Cruz Mean Holy Cross in Spanish and Portuguese
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See also: Special:PrefixIndex/Santa Cruz and All pages with titles containing "Santa Cruz"