American Phage Group
Bacteriophage: a very simple model organism[bewerken]
Electron micrograph of bacteriophages attached to a bacterial cell. These viruses are the size and shape of coliphage T1
Structure of Bacteriophage T4
Discovery of bacteriophages[bewerken]
Frederick W. Twort the original discoverer in 1915 of bacteriophages (viruses that infect bacteria)
Origins of the Phage Group[bewerken]
Influence of physical scientists in biology[bewerken]
Max Delbrück: a physicist-turned biologist[bewerken]
Lytic cycle, compared to lysogenic cycle
Salvador E. Luria ca. 1969
Salvador Luria and his wife Zella, on the beach at Cold Spring Harbor
Started of the Phage Group[bewerken]
The phage group started around 1940, after Delbrück and Luria had met at a physics conference. Delbrück and Luria began a series of collaborative experiments on the patterns of infection for different strains of bacteria and bacteriophage.
Salvador Luria and Max Delbrück at Cold Spring Harbor Laboratory
Luria–Delbrück experiment (1943)[bewerken]
The Luria–Delbrück experiment (1943) (also called the Fluctuation Test) demonstrates that in bacteria, genetic mutations arise in the absence of selection, rather than being a response to selection.
Phage course at Cold Spring Harbor Laboratory (1945)[bewerken]
Apart from direct collaborations, the main legacy of the phage group resulted from the yearly summer phage course, starting in 1945, at Cold Spring Harbor Laboratory.
Notable scientists associated with the Phage Group[bewerken]
Seymour Benzer with a Drosophila model, 1974