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A-SEL1L-Mutation-Links-a-Canine-Progressive-Early-Onset-Cerebellar-Ataxia-to-the-Endoplasmic-pgen.1002759.s007.ogv(Ogg multiplexed audio/video file, Theora/Vorbis, length 1 min 37 s, 640 × 480 pixels, 1.71 Mbps overall)

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English: Gait. Video shows the normal gait of an unaffected three months old Finnish Hound puppy and the altered gait of two affected similarly aged puppies. Note the difficulty of the affected puppies to control limb movements (ataxia), particularly in the hind limbs. Affected puppies present with swaying of the whole body (truncal ataxia) and abnormal postures, which are caused by the coordination difficulties. The puppies struggle with movement coordination, especially when the direction or speed of the movement changes or when the movement is initiated or stops abruptly. This is caused by inability to control the distance and scale of the movement (dysmetria), which leads to too short or too long steps.
Source Video S1 from Kyöstilä K, Cizinauskas S, Seppälä E, Suhonen E, Jeserevics J, Sukura A, Syrjä P, Lohi H (2012). "A SEL1L Mutation Links a Canine Progressive Early-Onset Cerebellar Ataxia to the Endoplasmic Reticulum–Associated Protein Degradation (ERAD) Machinery". PLOS Genetics. DOI:10.1371/journal.pgen.1002759. PMID 22719266. PMC: 3375262.
Author Kyöstilä K, Cizinauskas S, Seppälä E, Suhonen E, Jeserevics J, Sukura A, Syrjä P, Lohi H
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