File:About Lulu and Nana- Twin Girls Born Healthy After Gene Surgery As Single-Cell Embryos.webm

From Wikimedia Commons, the free media repository
Jump to navigation Jump to search

Original file(WebM audio/video file, VP9/Opus, length 4 min 43 s, 3,840 × 2,160 pixels, 22.67 Mbps overall)


English: Two Chinese girls, who we'll call Lulu and Nana to protect their privacy, were born healthy a few weeks ago. Their mother Grace started her pregnancy by regular IVF with one difference: right after sending her husband's sperm into her eggs, an embryologist also sent in CRISPR/Cas9 protein and instructions to perform a gene surgery intended to protect the girls from future HIV infection. The surgery reproduces a natural genetic variation shared by more than 100 million people of primarily European origin that confers strong resistance to initial HIV-1 infection and disease progression. While CRISPR/Cas9 has been studied in human cells and in early clinical trials, gene surgery in embryos intended for pregnancy has not previously been reported. Safety remains a key concern, particularly for unintended changes to the genome. To assess the girls' genomes for safety after the surgery, multiple whole genome and targeted deep sequencing techniques were used before implantation, during the pregnancy, and now after birth. These data indicate the girls' genomes' were changed as intended by the gene surgery, but no off-target editing or large deletions occurred. Further assessments to confirm these findings will be conducted over the next year. We will publish our full data soon. Jiankui He Lab Website:
Source YouTube : About Lulu and Nana: Twin Girls Born Healthy After Gene Surgery As Single-Cell Embryos
Author The He Lab


This video, screenshot or audio excerpt was originally uploaded on YouTube under a CC license.
Their website states: "YouTube allows users to mark their videos with a Creative Commons CC BY license."
To the uploader: You must provide a link (URL) to the original file and the authorship information if available.
w:en:Creative Commons
This file is licensed under the Creative Commons Attribution 3.0 Unported license.
Attribution: The He Lab
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

This file, which was originally posted to YouTube, was reviewed on by the administrator or reviewer Jeff G., who confirmed that it was available there under the stated license on that date.

File history

Click on a date/time to view the file as it appeared at that time.

current01:23, 27 November 20184 min 43 s, 3,840 × 2,160 (765.83 MB)Roy17 (talk | contribs)Imported media from
  • You cannot overwrite this file.

File usage on other wikis

The following other wikis use this file:

Transcode status

Update transcode status
FormatBitrateDownloadStatusEncode time
VP9 2160P10.32 Mbps
Download file
Completed 02:49, 27 November 20181 h 25 min 46 s
VP9 1440P5.21 Mbps
Download file
Completed 02:23, 27 November 201859 min 44 s
VP9 1080P2.49 Mbps
Download file
Completed 02:00, 27 November 201836 min 52 s
VP9 720P1.13 Mbps
Download file
Completed 01:46, 27 November 201823 min 8 s
VP9 480P630 kbps
Download file
Completed 01:39, 27 November 201816 min 11 s
VP9 360P387 kbps
Download file
Completed 01:34, 27 November 201811 min 29 s
VP9 240P250 kbps
Download file
Completed 01:33, 27 November 20189 min 55 s
VP9 180P204 kbps
Download file
Completed 01:31, 27 November 20188 min 21 s
VP9 120P154 kbps
Download file
Completed 01:30, 27 November 20187 min 3 s
WebM 1080P4.13 Mbps
Download file
Completed 01:56, 27 November 201832 min 36 s
WebM 720P1.93 Mbps
Download file
Completed 01:43, 27 November 201819 min 25 s
WebM 480P1.09 Mbps
Download file
Completed 01:36, 27 November 201812 min 41 s
WebM 360P581 kbps
Download file
Completed 01:34, 27 November 201810 min 26 s
WebM 240P326 kbps
Download file
Completed 01:30, 27 November 20187 min 10 s
WebM 160P211 kbps
Download file
Completed 01:29, 27 November 20185 min 56 s