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Original file (Ogg multiplexed audio/video file, Theora/Vorbis, length 16 s, 1,066 × 718 pixels, 472 kbps overall)
English: The effect of factor VIII product half-life on the dynamics of thrombin generation over time post administration of fVIII. Each unit of time (spanning 1900–1921) in the video represents 8 hours. Thrombin generating capacity was simulated by inputting a single subject's (H1 from Figure 4) factor levels into our mathematical model. The theoretical fVIII products used here have half-lives of 6, 12.2, 18 and 24 hours. By definition the 6 hour product decays much faster than products with longer half-lives and therefore the thrombin generating capacity of the 6 hour product declines fastest followed by the 12.2, 18 and 24 hour products.
|Source||Movie S4 from Foley J, Orfeo T, Undas A, McLean K, Bernstein I, Rivard G, Mann K, Everse S, Brummel-Ziedins K (2013). "From Principle to Practice: Bridging the Gap in Patient Profiling". PLOS ONE. DOI:10.1371/journal.pone.0054728. PMID 23372761. PMC: 3556038.|
|Author||Foley J, Orfeo T, Undas A, McLean K, Bernstein I, Rivard G, Mann K, Everse S, Brummel-Ziedins K|
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