File:HIV entry into T cell schematic.png

From Wikimedia Commons, the free media repository
Jump to navigation Jump to search
Original file(2,805 × 3,405 pixels, file size: 4.49 MB, MIME type: image/png)
Description

"Schematic Representation of the Key Structural Features of SIV and HIV-1 Entry into T Cells"

(A) Different stages of viral entry from budding, to maturation, to entry claw formation. For the SIV strain used here, viruses that are docked to the cell via an entry claw show very few, if any, viral spikes on their surface, whereas non-contacting viruses typically display between 60 and 100 spikes on their surface. The entry claw is composed of between five to seven anchors spanning the region between the virus and the cell, each ∼100 Å long, and spaced laterally by ∼150 Å.

(B and C) Two alternative models for viral entry. In the global fusion model (B), the formation of the entry claw is followed by progressive fusion of the viral membrane across its width, leading to merger of the contents of the viral membrane with the cellular membrane. In the local fusion model (C), the formation of the entry claw is followed by the creation of a local pore centered at one of the rods, leading to delivery of the viral core into the cell."

Date Published May 4, 2007
Source Sougrat R, Bartesaghi A, Lifson JD, et al (May 2007). "Electron tomography of the contact between T cells and SIV/HIV-1: implications for viral entry". PLoS Pathog. 3 (5): e63. PMID 17480119. doi:10.1371/journal.ppat.0030063 Direct link to image: http://www.plospathogens.org/article/showImageLarge.action?uri=info%3Adoi%2F10.1371%2Fjournal.ppat.0030063.g008
Author Rachid Sougrat, Alberto Bartesaghi, Jeffrey D. Lifson, Adam E. Bennett, Julian W. Bess, Daniel J. Zabransky, Sriram Subramaniam
Permission
(Reusing this file)

[1]

Other versions

JPG version

Licensing[edit]

w:en:Creative Commons
attribution
This file is licensed under the Creative Commons Attribution 2.5 Generic license.
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must attribute the work in the manner specified by the author or licensor (but not in any way that suggests that they endorse you or your use of the work).

PLOS
This file was published in a Public Library of Science journal. Their website states that the content of all PLOS journals is published under the Creative Commons Attribution 4.0 license (or its previous version depending on the publication date), unless indicated otherwise.

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current00:30, 11 June 2008Thumbnail for version as of 00:30, 11 June 20082,805 × 3,405 (4.49 MB)Fvasconcellos (talk | contribs){{Information |Description="Schematic Representation of the Key Structural Features of SIV and HIV-1 Entry into T Cells" (A) Different stages of viral entry from budding, to maturation, to entry claw formation. For the SIV strain used here, viruses that
  • You cannot overwrite this file.

The following 2 pages link to this file:

File usage on other wikis

The following other wikis use this file: