File:Mambalgin.png

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English: The crystal structure of mambalgin-1, a 57-residue protein of the three-finger toxin (3FTx) family isolated from the venom of the black mamba. Mambalgins are potent inhibitors of acid-sensing ion channels. Unlike most 3FTx proteins, which are usually neurotoxins, mambalgins produce analgesia through ASIC inhibition without apparent toxic effect in laboratory tests.

Rendered from PDB 5DU1:

Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition.

Mourier, G., Salinas, M., Kessler, P., Stura, E.A., Leblanc, M., Tepshi, L., Besson, T., Diochot, S., Baron, A., Douguet, D., Lingueglia, E., Servent, D.

(2016) J.Biol.Chem. 291: 2616-2629

PubMed: 26680001 PubMedCentral: PMC4742732

DOI: 10.1074/jbc.M115.702373
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Author Opabinia regalis

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current06:33, 8 July 2017Thumbnail for version as of 06:33, 8 July 2017506 × 720 (112 KB)Opabinia regalis (talk | contribs)fix crop
06:20, 8 July 2017Thumbnail for version as of 06:20, 8 July 2017600 × 900 (119 KB)Opabinia regalis (talk | contribs){{Information |Description ={{en|1=The crystal structure of mambalgin-1, a 57-residue protein of the three-finger toxin (3FTx) family isolated from the venom of the black mamba. Mambalgins are potent inhibitors of acid-sensing ion channels. Unlike m...
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