File:Mechanism of RNA interference.jpg

From Wikimedia Commons, the free media repository
Jump to navigation Jump to search

Original file(1,200 × 1,900 pixels, file size: 160 KB, MIME type: image/jpeg)

Captions

Captions

Add a one-line explanation of what this file represents
Description

Mechanism of RNA interference (RNAi). The appearance of double stranded (ds) RNA within a cell (e.g. as a consequence of viral infection) triggers a complex response, which includes among other phenomena (e.g. interferon production and its consequences) a cascade of molecular events known as RNAi. During RNAi, the cellular enzyme Dicer binds to the dsRNA and cleaves it into short pieces of ~ 20 nucleotide pairs in length known as small interfering RNA (siRNA). These RNA pairs bind to the cellular enzyme called RNA-induced silencing complex (RISC) that uses one strand of the siRNA to bind to single stranded RNA molecules (i.e. mRNA) of complementary sequence. The nuclease activity of RISC then degrades the mRNA, thus silencing expression of the viral gene. Similarly, the genetic machinery of cells is believe to utilize RNAi to control the expression of endogenous mRNA, thus adding a new layer of post-transciptional regulation. RNAi can be exploited in the experimental settings to knock down target genes of interest with a high specific and relatively easy technology

Date
Source RNA interference: learning gene knock-down from cell physiology doi:10.1186/1479-5876-2-39
Author Simone Mocellin and Maurizio Provenzano
Permission
(Reusing this file)
w:en:Creative Commons
attribution
This file is licensed under the Creative Commons Attribution 2.0 Generic license.
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

Other versions

[1]

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current17:37, 9 July 2007Thumbnail for version as of 17:37, 9 July 20071,200 × 1,900 (160 KB)Shizhao (talk | contribs){{Information |Description=Mechanism of RNA interference (RNAi). The appearance of double stranded (ds) RNA within a cell (e.g. as a consequence of viral infection) triggers a complex response, which includes among other phenomena (e.g. interferon product
  • You cannot overwrite this file.

There are no pages that use this file.

File usage on other wikis

The following other wikis use this file:

Structured data

Items portrayed in this file

depicts

no value