User talk:Edgar181

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Bolmantalate drawn wrongly[edit]

Bolmantalate.svg

Hey Edgar, the way you drew Bolmantalate is incorrect because it is made from 1-adamantylcarboxylic acid chloride (not 2).--Nuklear (talk) 21:31, 28 May 2015 (UTC)

Thanks for catching the error. I have uploaded a correction. Ed (Edgar181) 23:05, 6 July 2015 (UTC)

Wikipedia 'List of cocaine analogues' images needed.[edit]

Hello,

I notice you make a lot of molecular structure 2D images. I am currently restricted to a library computer and cannot make images for upload.

I was wondering if you could assist me in my endeavor of adding certain images for inclusion at the Wikipedia 'List of cocaine analogues' page.

What I need is mostly those from Singh's SAR of Cocaine paper (45 pages in on the page finder; pg. 970 or so as enumerated on the paper itself: the chemical structures 183a-(through)-d, 184a & b, 185a-d, 186-188 on 'Scheme 42', on pg. 50 (974) structures 196a-o, 197a-g, 198a-e, 199a & b, 200 & 201a-e ... and more down to page 61 or so; namely N-modified analogs & such.)

Any help making these would be greatly appreciated. Nagelfar (talk) 21:42, 24 February 2015 (UTC)

Thank you Ed! I added your images. The page is really coming along now. If you could help with the N-substitutions, the 3β-Carbamoyl, 3β-Alkylphenyltropane & 6-Alkyl-3-benzyltropane analogues that would help tremendously! I'm eager to at least get a few from every category eventually. (also before I noticed your help, I made a few .jpgs, some are still there. If you could make new .svgs of those, it would help with the consistency of the page too) Nagelfar (talk) 16:59, 16 March 2015 (UTC)
I also started a "List of methylphenidate analogues" page that needs some images. Nagelfar (talk) 23:27, 17 March 2015 (UTC)
For example, if there's any way to remake this image (of the 'restricted rotational analog' of methylphenidate) I would be much in your debt! Nagelfar (talk) 23:47, 17 March 2015 (UTC)
I would be happy to make those images for you. But unfortunately, I can't do them right away (I have a family member in the hospital and am unusually busy at work). I should be able to get to them before too long though. Ed (Edgar181) 01:39, 18 March 2015 (UTC)
Hey, I'm just happy to have someone willing to help me with this..! My best wishes for you & yours and my earnest condolences to your family in the hospital. When you get to it on your own time just give me a nudge and I'll incorporate them. Nagelfar (talk) 17:51, 18 March 2015 (UTC)
Noticed the new images from a few days back. I included them. You don't know how much I appreciate the help, I've had this page sitting dormant since dec. '07, and finally started hammering away at it myself but I'm stuck when it comes to images. You have my gratitude. Nagelfar (talk) 20:52, 23 March 2015 (UTC)
I'm glad to help. Sorry I forgot to leave a message for you here to let you know that I had uploaded some more. I will get to more of them soon. Ed (Edgar181) 01:23, 24 March 2015 (UTC)
Can't wait. Glad your glad; this has been a page I've wanted to get done-well for many years. Nagelfar (talk) 19:59, 25 March 2015 (UTC)
Hello Edgar, hope things are better with you. I'm on pins & needles expectantly for that "soon". All I'm really concerned with getting are the '3β-Alkylphenyltropane analogues', '6-Alkyl-3-benzyltropane analogues', & the few 'Piperidine homologues' then I'd say my page is finally complete! All the best. Nagelfar (talk) 18:25, 1 April 2015 (UTC)
OK, I created and uploaded some more. I'm not sure I've gotten all that you want or not. If there are more you need, just let me know the compound numbers from the Singh paper. Ed (Edgar181) 23:26, 3 April 2015 (UTC)
Awesome. Yes I do notice I needed more; Tropane fused #222, "pseudococaine", #225a—e, #211a—j, #212.... are highest priority, then if you can get to it later, #237b—f, #238b—f, #239a—f, #240a—f... and then lowest priority would be #401a—f, #402a—e & #403a—d..... you could just give me an "R"-substitution image like user Nuklear did for me at File:196a-o.svg File:197a-d.svg & File:197f.svg for those last ones. It would save time and be easier. I *really* appreciate the work, and no rush at all, but since you asked, that would make me feel that the page is most fully complete. ;-) (also do you know anything about the reagents mentioned in some papers: [2H5-phenyl]-cocaine &/or [2H3-N-methyl]-cocaine? I'd like to have those too, higher priority than the other stuff, because I feel the current content is too centered on Singh's paper and not from enough disparate sources.) Nagelfar (talk) 18:54, 4 April 2015 (UTC)
I also wanted to know if you'd help me with the List of phenyltropanes page. I don't need images for that one, what I need is your discriminating eye to see which RTI#s are the same as Singh's enumerated system, and which ones user Nuklear omitted. (he confessed he's bored of adding to the chemistry sections of Wikipedia and I'm adopting the page from him in this capacity). I will incorporate the tablature of whatever #'d compounds Nuklear hasn't put in there from their RTI equivalent. He says many of the "meta-substituted" ones he neglected to add (ones with more than a single substitution/modification), and I did the only one he concretely confirmed as not having added (16a—e, 17a—f). Half of Singh's paper is on the phenyltropanes, so there may be quite a number, but simply give me the numbers and I'll do all the work, and be grateful that you can spot the ones I need to put in there for me. Most esteemed regards, _Nagelfar (talk) 23:13, 4 April 2015 (UTC)
Sure, I'll take a look and see what I can work out. Ed (Edgar181) 23:28, 4 April 2015 (UTC)
Great! Like I said, you just give the numbers (as I did for you for the pictures) and I'll do everything as for implementing the tables, names, schemes & figures. I want to get that page as comprehensive as possible. Integrating everything from that paper is my goal (and getting a substantial amount more from other sources, eventually in the long term.) Oh and hey, if you know about chemistry, can you perhaps find a citation for me that when two substitutions are individually made to a molecule either one alone makes the parent compound weaker, but when made together on one structure they become ("stronger / more selective / higher affinity, etc.") more efficacious than said parent compound? I believe oxycodone is an example, but I can only find it's one precursor, codeinone, as referenced being weaker than codeine. It has another intermediate, if I recall correctly, that is also weaker (than either codeine or morphine, I forget which) I think it's "7,8-dihydrocodeine" or "14-hydroxylcodeine" but I can't find a source saying for sure both that a) they're intermediates in the synthesis of oxycodone and b) it is weaker than (not just oxycodone but) it's own parent compound. I'm trying to prove a point on the analogs list page but I need a verified citation. OK, it's no worry if you don't have an example I can source though, I'm more concerned about filling out the phenyltropanes page with what it's missing in all honesty. ;-) Nagelfar (talk) 18:34, 5 April 2015 (UTC)

The list of phenyltropanes page is very disorganized and inconsistent, so it is really hard to figure out which of the Singh compounds are present and which aren't. There are some errors that complicate things too: for example, in the table in the section titled "3-Substituted-isoxazol-5-yl" some of the R groups appear to be incorrect for the RTI structures they are matched with. After a brief look, I think Singh's compounds 23, 24, 25, 26, and 29 are missing from the page, but I'm not sure. In all honesty, that page is such a mess that I'm not sure it's worth the effort to try to figure it out.  :/ As for your question about an example where two changes that are independently negative which are positive when made together, nothing comes immediately to mind. But it is certainly a plausible situation in medicinal chemistry. I'll keep it in mind and maybe something will come to me. Ed (Edgar181) 20:22, 5 April 2015 (UTC)

Hmmm, well any improvements you can suggest, I want to salvage that phenyltropanes page. Perhaps begin one step at a time with remedying the mismatched R group to its proper structuring (Nuklear did add an image for me that had a free floating nitrogen I had to get someone else to correct, and even now, if you notice that image, the lines don't go all the way up to the "R" because the image was corrected by someone with even less knowledge about chemistry than I, which is saying something (they simply had the means to make a meaningful edit to the appropriate image file type). Hopefully it's not too daunting to assist me if you can get around to it. But if it's less burdensome to simply render those final cocaine analogs at the top of the paragraph four up from this one, that I'd be ecstatic & honored for so thorough a job having at my disposal your expertly done images. (those being, yet again, the "fused-tropane", the "6/7 tropane methoxycocaine & pseudococaine" and the "4′-iodo-2β" (/w R-image(s) on this last one if possible) also the "Benzylidene 6-alkyl-3-benzyl" & even *just* R-images for the catalytic TSA haptens (i.e. 401a—403d). Nagelfar (talk) 21:32, 5 April 2015 (UTC)
Thank you Ed. Wow.... I think you omitted "pseudococaine" but that's it!!!! Well done Sir!!!!! (you even got my reagents!!!!!) Nagelfar (talk) 00:39, 7 April 2015 (UTC)
I added "23, 24, 25, 26" series table (likely get to 29 later) at the list of phenyltropanes article. Besides pseudococaine, perhaps you could make a single R-sub.-image of the X/R substitutions for those phenyltropanes too. (Should I put the table in a different place? I want to rehabilitate that page as much as possible while expanding it). Your services are appreciated, as always, thank you Ed. Nagelfar (talk) 23:58, 9 April 2015 (UTC)

Hey Ed, I got to the 29 series (sans-image) at the phenyltropane's list also. So if you know where I can start in other ways to rehabilitate that page, drop me a line. Also if you want to do just the "R" substitution images for the benztropine & GBR compounds on the cocaine analog list, that'd be welcomed with open arms. Best regards and much thanks for all the work (yet again). Nagelfar (talk) 20:55, 14 April 2015 (UTC)

I should be able to make some more images tomorrow or this weekend. Ed (Edgar181) 14:32, 16 April 2015 (UTC)
Great. Also I've corresponded a bit with user:Meodipt, he started a new MPH analog and has contributed many pictures before, I'm attempting to get his input on salvaging the phenyltropanes list and passed along what you have said here, above. All the best, _Nagelfar (talk) 02:44, 17 April 2015 (UTC)
Hey, Ed; do you know anyone else with some level of chemistry devotion to Wikipedia who may be willing to help me out? I just want someone to tell me what RTI/WIN/WF structures are the same as what Singh numbers so I can add Singh's binding affinities to those same tables in a 'break' below the ones RTI, et al. given with a notation saying it's the values that Singh & co. extrapolated for the same transporter sites for that same compound. That would be a huge boon for me, again, I'll do all the inclusions, I just need someone willing to tell me which compounds are 1:1 the same between those two groupings. Nagelfar (talk) 23:46, 19 April 2015 (UTC)
Looks like you couldn't get to it this weekend, no worries. I'm just mentioning in-case perhaps you forgot to associate it to the 'cocaine analogues associated media' page here at Commons. Regards. Nagelfar (talk) 21:57, 21 April 2015 (UTC)
Been busy for another weekend eh? Most of the benztropine analogs could be covered with one or two "R"-substitution images, just need someone with the *.svg making utensils. ;-j well, hope everything is doing well with you. Just keeping in contact is all. Regards, Nagelfar (talk) 00:46, 28 April 2015 (UTC)
Sorry, I've been busy with work and at home. I haven't had much time at all for Wikipedia lately. Ed (Edgar181) 22:15, 3 May 2015 (UTC)
No worries. I have all the time in the world. I started the page in Dec. 2007 with the hopes someone more astute with chemistry than myself would contribute to it so I could be educated on the topic. It ended up taking me seven years of studying academic articles myself until I got the gist of it, just so I knew, at least partially and without training of any sort in the field, how to understand the publishings well enough to accurately transclude the information in them to WP. I can wait and go at your pace, just let me know when you do get to it. :-] Nagelfar (talk) 02:09, 6 May 2015 (UTC)
There is really only 6 (six) R-substitution images needed for the benztropine analogs on the cocaine analogs page. If anything seems daunting with the GBRs, just start with the benztropines. ;) Nagelfar (talk) 18:14, 21 May 2015 (UTC)
I know you're probably swamped, but those six benztropine R-substitution images would tide me over for a great long while and prevent a novel from being written on your talk page by yours truly. Do those and I won't hassle you further for at least a month. :-P Nagelfar (talk) 01:22, 28 May 2015 (UTC)
Hope your family issues are working out Ed. I'm praying for you. Nagelfar (talk) 18:52, 12 June 2015 (UTC)
Thank you very much. I appreciate that. I just want to let you know that I haven't forgotten about you. I think I will have time soon. (I've probably said that before though). Ed (Edgar181) 23:06, 6 July 2015 (UTC)

File:Spironolactone structure.png[edit]

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Category:N-morpholine_N-oxide[edit]

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Category:Glycerides[edit]

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