File:Phototransduction.png
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DescriptionPhototransduction.png |
English: Representation of molecular steps in photoactivation (modified from Leskov et al., 2000). Depicted is an outer membrane disk in a rod. Step 1: Incident photon (hv) is absorbed and activates a rhodopsin by conformational change in the disk membrane to R*. Step 2: Next, R* makes repeated contacts with transducin molecules, catalyzing its activation to G* by the release of bound GDP in exchange for cytoplasmic GTP. The α and γ subunits Step 3: G* binds inhibitory γ subunits of the phosphodiesterase (PDE) activating its α and β subunits. Step 4: Activated PDE hydrolyzes cGMP. Step 5: Guanylyl cyclase (GC) synthesizes cGMP, the second messenger in the phototransduction cascade. Reduced levels of cytosolic cGMP cause cyclic nucleotide gated channels to close preventing further influx of Na+ and Ca2+.
Deutsch: Repräsentation der molekularen Schritte der Lichtaktivierung (verändert nach Leskov et al., 2000). Es wird die äussere Membranschiebe eines Stäbchens abgebildet.
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Date | |||
Source | http://en.wikipedia.org/wiki/File:Phototransduction.png | ||
Author | Jason J. Corneveaux, wiki user: Caddymob (talk) | ||
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Other versions | Derivative works of this file: Phototransduction uk.png |
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current | 15:42, 18 April 2010 | 1,327 × 561 (344 KB) | Thomas.haslwanter (talk | contribs) | {{Information |Description=Representation of molecular steps in photoactivation (modified from Leskov et al., 2000). Depicted is an outer membrane disk in a rod. Step 1: Incident photon (hv) is absorbed and activates a rhodopsin by conformational change i |
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