File:Antidepressant types of effects uk.png

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Українська: Ефекти антидепресантів на нейрони з плином часу. Спочатку підвищується кількість нейротрансмітера, який впливає на свої рецептори (миттєві ефекти). Зв'язування з рецептором ініціює каскад внутрішньоклітинних реакцій: інформація від рецептора через декілька клітинних месенджерів доходить до ДНК та активує фактори транскрипції та подальшу експресію генів (підгострі ефекти). Як наслідок, відбувається синтез нейротропних факторів, котрі забезпечують виживання нейронів та появу нових клітин, рецепторів та іонних каналів, які необхідні для синаптогенезу та утворення нових зв'язків для правильної роботи нейрональних мереж (хронічні, або віддалені ефекти).
English: Effects of antidepressants on neurons in the course of time. Firstly, an antidepressant causes the elevation of a neurotransmitter that binds to its receptors (immediate effect). Binding initiates signal transduction cascades via intracellular messengers which eventually leads to activation of transcription factors and genes expression (subacute effect). As a result, synthesis of BDNF, which has a pivotal role in maintaining neurons and neurogenesis, receptors and ion channels needed for synaptogenesis and creation of new connections in neural networks occurs (long-term effect).
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