File:Biological role of serine hydroxymethyltransferase.png
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Biological role of serine hydroxymethyltransferase
Summary[edit]
| Description |
English: Biological role of SHMT. a Serine–glycine interconversion catalyzed by SHMT. THF = tetrahydrofolate, CH2-THF = N-5,N-10-methylenetetrahydrofolate. The red dot highlights the carbon that is transferred from Ser to THF. b Schematic overview of hSHMT function. MTHFD = methylenetetrahydrofolate dehydrogenase-cyclohydrolase, CH2-THF = N-5,N-10-methylenetetrahydrofolate, CH+-THF = 5,10-methenyltetrahydrofolate, CHO-THF = 10-formyltetrahydrofolate, NADP+ = Nicotinamide adenine dinucleotide phosphate, NADPH = NADP+ reduced form. c SHMT, dihydrofolate reductase (DHFR), and thymidylate synthase (TS) in the folate cycle. THF = tetrahydrofolate, CH2-THF = 5,10-methylenetetrahydrofolate, DHF = dihydrofolate, FdUMP = fluorodeoxyuridine-5′-monophosphate, dUMP = deoxyuridine monophosphate, dTMP = deoxythymidine monophosphate |
| Date | |
| Source | https://www.nature.com/articles/s41467-019-08833-7 |
| Author | Hiroshi Nonaka, Yuki Nakanishi, Satoshi Kuno, Tomoki Ota, Kentaro Mochidome, Yutaro Saito, Fuminori Sugihara, Yoichi Takakusagi, Ichio Aoki, Satoru Nagatoishi, Kouhei Tsumoto & Shinsuke Sando |
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| current | 15:14, 4 June 2022 | | 1,982 × 1,155 (357 KB) | CopperKettle (talk | contribs) | Uploaded a work by Hiroshi Nonaka, Yuki Nakanishi, Satoshi Kuno, Tomoki Ota, Kentaro Mochidome, Yutaro Saito, Fuminori Sugihara, Yoichi Takakusagi, Ichio Aoki, Satoru Nagatoishi, Kouhei Tsumoto & Shinsuke Sando from https://www.nature.com/articles/s41467-019-08833-7 with UploadWizard |
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