File:CFS-brain-activity 01.png

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Difference between adolescents with chronic fatigue syndrome and healthy controls shows less salient network activity in certain regions of the brain

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English: Salience network (SN) functional connectivity group difference map and its relationship with fatigue symptoms. Fig 1 difference map, subtracting adolescent CFS SN maps from healthy comparison (HC) SN maps, demonstrates less intrinsic SN connectivity to brain regions within the SN (right middle insula [R midINS], right posterior insula [R posINS], and right anterior insula [R antINS] (left). Bar graph shows the mean and standard error Z scores for functional connectivity in each group (middle). Right posterior insula connectivity strength decreases with greater fatigue symptoms in adolescent with Chronic Fatigue Syndrome but not with HC (right). Dark circles represent individual patients with CFS and lighter circles represent HC participants. Activation height is thresholded at the P < 0.05 (corrected) level.
Date
Source https://doi.org/10.1371/journal.pone.0159351
Author Citation: Wortinger LA, Endestad T, Melinder AMD, Øie MG, Sevenius A, Bruun Wyller V (2016) Aberrant Resting-State Functional Connectivity in the Salience Network of Adolescent Chronic Fatigue Syndrome. PLoS ONE 11(7): e0159351. https://doi.org/10.1371/journal.pone.0159351

Citation: Wortinger LA, Endestad T, Melinder AMD, Øie MG, Sevenius A, Bruun Wyller V (2016) Aberrant Resting-State Functional Connectivity in the Salience Network of Adolescent Chronic Fatigue Syndrome. PLoS ONE 11(7): e0159351. https://doi.org/10.1371/journal.pone.0159351

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