File:Fimmu-11-579250-g002.jpg
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Key components of the innate immune response to SARS-CoV-2.
Summary[edit]
| Description |
English: Key components of the innate immune response to SARS-CoV-2. Antigen presenting cells (APCs), such as monocytes, macrophages, and dendritic cells (DCs), recognize pattern associated molecular patterns (PAMPs) expressed by SARS-CoV-2 via their pattern recognition receptors (PRRs), such as toll-like receptor (TLR) 3 and 7. This activates intracellular signaling pathways leading to the expression of type 1 and 3 interferons (IFNs), which in turn activate innate immune cells to produce pro-inflammatory cytokines and chemokines. This leads to an influx and activation of neutrophils, further APCs and other innate immune cells, such as natural killer (NK) cells. |
| Date | |
| Source |
Flanagan KL, Best E, Crawford NW, Giles M, Koirala A, Macartney K, Russell F, Teh BW and Wen SCH (2020) Progress and Pitfalls in the Quest for Effective SARS-CoV-2 (COVID-19) Vaccines. Front. Immunol. 11:579250. https://doi.org/10.3389/fimmu.2020.579250 |
| Author | Katie L. Flanagan, Emma Best, Nigel W. Crawford, Michelle Giles, Archana Koirala, Kristine Macartney, Fiona Russell, Benjamin W. Teh, and Sophie CH Wen, on behalf of the Australasian Society for Infectious Diseases (ASID) Vaccination Special Interest group (VACSIG) |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 14:30, 1 February 2021 | | 893 × 505 (232 KB) | Guest2625 (talk | contribs) | Uploaded a work by Katie L. Flanagan, Emma Best, Nigel W. Crawford, Michelle Giles, Archana Koirala, Kristine Macartney, Fiona Russell, Benjamin W. Teh, and Sophie CH Wen, on behalf of the Australasian Society for Infectious Diseases (ASID) Vaccination Special Interest group (VACSIG) from Flanagan KL, Best E, Crawford NW, Giles M, Koirala A, Macartney K, Russell F, Teh BW and Wen SCH (2020) Progress and Pitfalls in the Quest for Effective SARS-CoV-2 (COVID-19) Vaccines. Front. Immunol. 11:579... |
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