File:Foliculo desarrollo Gonadotrop LH.jpg

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Español: Figura 4. Señalización de LH en los folículos ováricos.

Las etapas finales de la maduración del folículo y la ovulación dependen de la unión de la LH en los folículos ováricos.
Las etapas finales de la maduración del folículo y la ovulación dependen de la unión de la LH al LHCGR en las células de la granulosa mural (GC).
La unión de LH a LHCGR activa Gs, lo que aumenta los niveles de cAMP dentro de las GC murales. Las GC estimulados por LH expresan factores de crecimiento, incluidos AREG y EREG, que pueden estimular la señalización de EGFR.
Esto da como resultado una activación de las vías RAS-RAF-MEK que fosforilan ERK1/2. pERK1/2 activado estimula la expresión de Pgr y Ptgs2, que son necesarios para lograr una ovulación exitosa. Por el contrario, las vías cAMP y ERK1/2 inhiben la expresión de NppcmRNA (que codifica CNP) y NPR2, respectivamente.

Dado que CNP y NPR2 desempeñan un papel importante en el mantenimiento de la detención meiótica en los folículos preovulatorios, la inhibición de la señalización de CNP/NPR2 permite que los ovocitos reanuden la meiosis.
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ERβ Regulation of Gonadotropin Responses during Folliculogenesis

Int. J. Mol. Sci. 2021, 22(19), 10348; https://doi.org/10.3390/ijms221910348
Author Eun B. Lee , V. Praveen Chakravarthi , Michael W. Wolfe , M.A. Karim Rumi

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