File:Magnesium deficit, inflammation, oxidative stress, and aging.webp
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DescriptionMagnesium deficit, inflammation, oxidative stress, and aging.webp |
English: Mg deficit, inflammation, oxidative stress, and aging. The relationship of low Mg status, generated by multiple factors (i.e., low Mg intake and absorption, Mg transport genetic defects, obesity, type 2 diabetes mellitus (T2DM) and cardio-metabolic syndrome, polypharmacotherapy, and alcohol abuse), which may trigger an increased production of free radicals (ROS), oxidative damage, and activation of redox signaling (i.e., NF-KB, AP-1, and other transcription factors). The elevation in oxidative stress may lead to the release of inflammatory mediators conforming a state of chronic low-grade inflammation, which has been proposed to accompany aging and called “inflammaging”. TRPM7: Transient Receptor Potential cation channel, subfamily M, member 7; ROS: reactive oxygen species; NF-KB nuclear factor kappa-light-chain-enhancer of activated B cells; AP-1: activator protein 1; TNF-alpha: tumor necrosis factor-alpha; IL: interleukin; CRP: C-reactive protein. |
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Barbagallo, M.; Veronese, N.; Dominguez, L.J. Magnesium in Aging, Health and Diseases. Nutrients 2021, 13, 463. https://doi.org/10.3390/nu13020463 |
Author | Barbagallo, M.; Veronese, N.; Dominguez, L.J. |
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current | 20:36, 6 February 2022 | 3,066 × 1,906 (957 KB) | Balkanique (talk | contribs) | Uploaded a work by Barbagallo, M.; Veronese, N.; Dominguez, L.J. from Barbagallo, M.; Veronese, N.; Dominguez, L.J. Magnesium in Aging, Health and Diseases. Nutrients 2021, 13, 463. https://doi.org/10.3390/nu13020463 with UploadWizard |
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