File:PVM Exopher Labeled-1.jpg
Jump to navigation
Jump to search
Size of this preview: 692 × 600 pixels. Other resolutions: 277 × 240 pixels | 554 × 480 pixels | 886 × 768 pixels | 1,198 × 1,038 pixels.
Original file (1,198 × 1,038 pixels, file size: 72 KB, MIME type: image/jpeg)
Captions
Captions
Three exophers, indicated by white arrows have been extruded by a C. elegans PVM mechanosensory neuron, in vivo.
Summary[edit]
| Description |
English: In this image, taken at 100x magnification on a confocal microscope, a Caenorhabditis elegans PVM mechanosensory neuron is expressing two transgenic fluorescent proteins: mCherry, which is soluble in the cytoplasm and labels the soma and the axon in red, and GFP which localizes to the mitochondria and labels them in green. A dye, 4′,6-diamidino-2-phenylindole (DAPI), labels the nucleus in the neuron and the surrounding nuclei of the hypodermis in blue. Three exophers, large membrane-bound extracellular vesicles, are indicated by white arrows. Exophers are produced by neurons and myocytes across phyla, and represent an exocytic mechanism to maintain homeostasis by ejecting protein aggregates, excess membrane, and damaged organelles from the cell body. Exophers are distinguished from other extracellular vesicles by their distinct mechanism of biogenesis and their large diameter, which can be as large as the cell that extruded it. Exophers may play a role in aggregate spread in human diseases such as Alzheimer's disease or Huntington's disease.
Arnold ML, Cooper J, Grant BD, Driscoll M. Quantitative Approaches for Scoring in vivo Neuronal Aggregate and Organelle Extrusion in Large Exopher Vesicles in C. elegans. J Vis Exp. 2020 Sep 18;(163):10.3791/61368. doi: 10.3791/61368. PMID: 33016946 |
| Date | |
| Source | Own work |
| Author | Guasp |
Licensing[edit]
I, the copyright holder of this work, hereby publish it under the following license:
This file is licensed under the Creative Commons Attribution 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
 |
This file was uploaded as part of Wiki Science Competition 2021. |
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 05:01, 31 December 2021 | | 1,198 × 1,038 (72 KB) | Guasp (talk | contribs) | Uploaded own work with UploadWizard |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
File usage on other wikis
The following other wikis use this file:
- Usage on en.wikipedia.org
