File:Paraneoplastic Pemphigus.JPG
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English: Paraneoplastic Pemphigus is a rare autoimmune disease associated primarily with lymphoproliferative diseases, (benign or malignant). It is characterized clinically by numerous, chronic persistent and painful oral ulcerations, together with various skin eruptions like Erythema multiformis; histologically by the presence of subepithelial bullae and cleft formation and immunologically by the detection of autoabs against intracellular desmosomal and hemidesmosomal plaque proteins (envo, peri, desmo-plakin and alpha 2macrobulin like Ag). Early detection and treatment (i.e surgical removal) of the primary tumor together with i.v administration of immunoglobulins is the treatment of choice for this lethal bullous disease. Mvskoke: Η Παρανεοπλασματική Πέμφιγα είναι μια σπάνια αυτοάνοσος νόσος που σχετίζεται με τη ύπαρξη ενός καλοήθους κακοήθους νεοπλάσματος. Χαρακτηρίζεται, κλινικά, από πολυάριθμες, χρόνιες, επίμονες και επώδυνες ελκώσεις στο στόμα μαζί με
δερματικές βλάβες που μοιάζουν με αυτές του Πολυμόρφου Ερυθήματος, ιστολογικά με τη παρουσία υποεπιθηλιακών φυσαλίδων και ανοσολογικά με την ανίχνευση αυτοαντισωμάτων έναντι ενδοκυτταρίων δεσμοσωματικών και ημιδεσματικών πρωτεϊνών της οικογενείας των πλακινών. Έγκαιρη διάγνωση και θεραπεία (π.χ. χειρουργική αφαίρεση του νεοπλάσματος μαζί με τη ταυτόχρονη χορήγηση σφαιρινών ενδοφλέβια) είναι απαραίτητα για την αντιμετώπιση αυτής της επικίνδυνης για τη ζωή πομφολυγώδους νόσου.English: Paraneoplastic Pemphigus |
| Date | |
| Source | Own work |
| Author | Dimitrios Malamos |
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This image was uploaded as part of European Science Photo Competition 2015. |
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| current | 13:10, 23 November 2015 | | 3,888 × 2,592 (2.55 MB) | Dmalamos (talk | contribs) | User created page with UploadWizard |
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