File:Replication stress and its consequences in mitosis.png

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Replication stress and its consequences in mitosis

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English: Replication stress from either endogenous or exogenous causes (red circles) leaves chromosomal segment unreplicated or interwinded leading to anaphase bridges formation. Single-ended DSB could lead to dicentric chromosome formation and thus, also, to anaphase bridge formation. Non-detected damages upon low replicative stress could be grouped in one detectable entity in G1: 53BP1 bodies and/or micronuclei. Replication stress also favors mitotic extra centrosomes and multipolar mitosis, thus amplifying mitotic catastrophes and genome instability to the whole genome.[1]
Date
Source https://doi.org/10.3390/genes6020267
Author Camille Gelot, Indiana Magdalou, and Bernard S. Lopez

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This file is licensed under the Creative Commons Attribution 4.0 International license.
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current23:05, 24 May 2020Thumbnail for version as of 23:05, 24 May 20202,200 × 3,200 (2.48 MB)Rob Hurt (talk | contribs)Uploaded a work by Camille Gelot, Indiana Magdalou, and Bernard S. Lopez from https://doi.org/10.3390/genes6020267 with UploadWizard

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