File:SPPS.jpg
SPPS.jpg (597 × 544 pixels, file size: 88 KB, MIME type: image/jpeg)
Captions
This picture shows the coupling step in solid peptide synthesis. The picture was drawn according to a synthesis described by L. P. Miranda [1].
The amino acid chain AAHYHTHKE with side chain protecting groups is bonded with glutamate (E) to a PAM resin. For the next coupling step, lysine is shown close to the end of the chain. Lysine is protected with Boc (Nα) and 2-chloro-benzyl-oxy-carbonyl (sidechain). It is activated with OBt.
Contents
Colors[edit]
green | resin |
---|---|
yellow | linker |
red | peptide main chain |
orange | peptide side chain |
light blue | side chain protecting groups |
blue | Boc group |
magenta | activating OBt group |
References[edit]
- ↑ Miranda, L. P. et al. 2001. Total chemical synthesis and chemotactic activity of human S100A12. FEBS Letters 488 85-90
Summary[edit]
DescriptionSPPS.jpg | Ball and stick visualisation of a solid phase peptide synthesis |
Date | |
Source | own work (drawn in PyMOL) |
Author | Felix Plasser |
Licensing[edit]
Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled GNU Free Documentation License.http://www.gnu.org/copyleft/fdl.htmlGFDLGNU Free Documentation Licensetruetrue |
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