File:Stepwise approach for managing asthma in youths greater than or equal to 12 years of age and adults.gif

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Stepwise_approach_for_managing_asthma_in_youths_greater_than_or_equal_to_12_years_of_age_and_adults.gif ‎(609 × 561 pixels, file size: 36 KB, MIME type: image/gif)

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Description
English: The stepwise approach is meant to assist, not replace, the clinical decision-making required to meet individual patient needs.
  • If alternative treatment is used and response is inadequate, discontinue it and use the preferred treatment before stepping up.
  • Zileuton is a less desirable alternative due to limited studies as adjunctive therapy and the need to monitor liver function. Theophylline requires monitoring of serum concentration levels.
  • In step 6, before oral systemic corticosteroids are introduced, a trial of high-dose ICS + LABA + either LTRA, theophylline, or zileuton may be considered, although this approach has not been studied in clinical trials.
  • Step 1, 2, and 3 preferred therapies are based on Evidence A; step 3 alternative therapy is based on Evidence A for LTRA, Evidence B for theophylline, and Evidence D for zileuton.
  • Step 4 preferred therapy is based on Evidence B, and alternative therapy is based on Evidence B for LTRA and theophylline and Evidence D for zileuton.
  • Step 5 preferred therapy is based on Evidence B.
  • Step 6 preferred therapy is based on (EPR-2 1997) and Evidence B for omalizumab.
  • Immunotherapy for steps 2-4 is based on Evidence B for house-dust mites, animal danders, and pollens; evidence is weak or lacking for molds and cockroaches.
  • Evidence is strongest for immunotherapy with single allergens.
  • The role of allergy in asthma is greater in children than in adults.
  • Clinicians who administer immunotherapy or omalizumab should be prepared and equipped to identify and treat anaphylaxis that may occur.
Date
Source Guidelines for the Diagnosis and Management of Asthma. NIH Publication no. 08-4051, 2007.
Author National Heart, Blood, and Lung Institute

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current17:29, 27 March 2012Thumbnail for version as of 17:29, 27 March 2012609 × 561 (36 KB)Pulmonological (talk | contribs)

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