File:Aging Cell - 2024 - Koncevičius - Epigenetic age oscillates during the day.pdf
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DescriptionAging Cell - 2024 - Koncevičius - Epigenetic age oscillates during the day.pdf |
English: Since their introduction, epigenetic clocks have been extensively used in aging, human disease, and rejuvenation studies. In this article, we report an intriguing pattern: epigenetic age predictions display a 24-h periodicity. We tested a circadian blood sample collection using 17 epigenetic clocks addressing different aspects of aging. Thirteen clocks exhibited significant oscillations with the youngest and oldest age estimates around midnight and noon, respectively. In addition, daily oscillations were consistent with the changes of epigenetic age across different times of day observed in an independant populational dataset. While these oscillations can in part be attributed to variations in white blood cell type composition, cell count correction methods might not fully resolve the issue. Furthermore, some epigenetic clocks exhibited 24-h periodicity even in the purified fraction of neutrophils pointing at plausible contributions of intracellular epigenomic oscillations. Evidence for circadian variation in epigenetic clocks emphasizes the importance of the time-of-day for obtaining accurate estimates of epigenetic age. |
Date | |
Source | https://onlinelibrary.wiley.com/doi/full/10.1111/acel.14170 |
Author | Karolis Koncevičius, Akhil Nair, Aušrinė Šveikauskaitė, Agnė Šeštokaitė, Auksė Kazlauskaitė, Audrius Dulskas, Artūras Petronis |
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current | 11:06, 21 April 2024 | 1,239 × 1,629, 8 pages (2.34 MB) | Koavf (talk | contribs) | Uploaded a work by Karolis Koncevičius, Akhil Nair, Aušrinė Šveikauskaitė, Agnė Šeštokaitė, Auksė Kazlauskaitė, Audrius Dulskas, Artūras Petronis from https://onlinelibrary.wiley.com/doi/full/10.1111/acel.14170 with UploadWizard |
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Short title | Epigenetic age oscillates during the day |
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Image title | Aging Cell 0.0:e14170 |
Identifier | doi:10.1111/acel.14170 |
Software used | Adobe InDesign 15.1 (Windows) |
Conversion program | Adobe PDF Library 15.0; modified using iText 4.2.0 by 1T3XT |
Encrypted | no |
Page size | 595.276 x 782.362 pts |
Version of PDF format | 1.7 |
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