File:Autosomal-Recessive-Transmission-of-a-Rare-KRT74-Variant-Causes-Hair-and-Nail-Ectodermal-Dysplasia-pone.0093607.g004.jpg

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Autosomal-Recessive-Transmission-of-a-Rare-KRT74-Variant-Causes-Hair-and-Nail-Ectodermal-Dysplasia-pone.0093607.g004.jpg ‎(676 × 353 pixels, file size: 96 KB, MIME type: image/jpeg)

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English: (A) Sections from a forearm skin biopsy of a healthy control individual show positive staining for Keratin-74 (KRT74; green) in the inner root sheath of the hair follicle. The nuclear envelope marker Lamin B1 (red) is used for co-staining (200x magnification). (B) Skin biopsy from forearm of individual V:3 with AR PHNED shows a hair follicle that stains negative for Keratin-74. Co-staining with Lamin B1 is normal (200x magnification). Dashed lines delineate the outer border of the inner root sheath, and the inner border of the root sheath with the medulla. From left to right: Brightfield (light) microscopy; Keratin-74 staining (KRT74); Lamin B1 staining and merge.
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Source Image file from Raykova D, Klar J, Azhar A, Khan T, Malik N, Iqbal M, Tariq M, Baig S, Dahl N (2014). "Autosomal Recessive Transmission of a Rare KRT74 Variant Causes Hair and Nail Ectodermal Dysplasia: Allelism with Dominant Woolly Hair/Hypotrichosis". PLOS ONE. DOI:10.1371/journal.pone.0093607. PMID 24714551. PMC: 3979697.
Author Raykova D, Klar J, Azhar A, Khan T, Malik N, Iqbal M, Tariq M, Baig S, Dahl N
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current20:34, 8 January 2016Thumbnail for version as of 20:34, 8 January 2016676 × 353 (96 KB)Recitation-bot (talk | contribs)Automatic upload of media from: doi:10.1371/journal.pone.0093607

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