File:Proteolytic activation of SREBF-controlled lipid biosynthesis.jpg
From Wikimedia Commons, the free media repository
Jump to navigation
Jump to search
Size of this preview: 800 × 505 pixels. Other resolutions: 320 × 202 pixels | 640 × 404 pixels | 945 × 597 pixels.
Original file (945 × 597 pixels, file size: 239 KB, MIME type: image/jpeg)
File information
Structured data
Captions
This image was uploaded in the JPEG format even though it consists of non-photographic data. This information could be stored more efficiently or accurately in the PNG or SVG format. If possible, please upload a PNG or SVG version of this image without compression artifacts, derived from a non-JPEG source (or with existing artifacts removed). After doing so, please tag the JPEG version with {{Superseded|NewImage.ext}} and remove this tag. This tag should not be applied to photographs or scans. If this image is a diagram or other image suitable for vectorisation, please tag this image with {{Convert to SVG}} instead of {{BadJPEG}}. If not suitable for vectorisation, use {{Convert to PNG}}. For more information, see {{BadJPEG}}. |
Summary[edit]
DescriptionProteolytic activation of SREBF-controlled lipid biosynthesis.jpg |
English: SREBF-1 is synthesized as inactive precursors in ER, where it resides in a complex with SCAP, a sterol sensor, and INSIG-1. Upon activation, when sterol levels are low, SCAP undergoes a conformational change and is released from INSIG. SCAP assists the transport of the precursor SREBF-1 to the Golgi apparatus followed by a two-step proteolytic cleavage thus releasing a transcriptionally active N-terminal domain. This domain is subsequently translocated to the nucleus, resulting in the expression of SREBF target genes. |
Date | |
Source | Own work |
Author | VeraOli |
Licensing[edit]
I, the copyright holder of this work, hereby publish it under the following license:
This file is licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- share alike – If you remix, transform, or build upon the material, you must distribute your contributions under the same or compatible license as the original.
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 20:01, 30 March 2014 | 945 × 597 (239 KB) | VeraOli (talk | contribs) | User created page with UploadWizard |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
File usage on other wikis
The following other wikis use this file:
- Usage on ar.wikipedia.org
- Usage on bs.wikipedia.org
- Usage on en.wikipedia.org
- Usage on hy.wikipedia.org
- Usage on mk.wikipedia.org
- Usage on uz.wikipedia.org
Metadata
This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong.
Orientation | Normal |
---|---|
Horizontal resolution | 150 dpi |
Vertical resolution | 150 dpi |