File:1-s2.0-S0022283615006762-gr1-C.jpg
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1-s2.0-S0022283615006762-gr1-C.jpg (512 × 410 pixels, file size: 163 KB, MIME type: image/jpeg)
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Description1-s2.0-S0022283615006762-gr1-C.jpg |
English: Schematic of the bacteriophage MS2 lifecycle. Virions initially bind to the sides of the bacterial pilus via the MP. MPs are an essential single-copy structural component of RNA phages. By a mechanism that remains largely obscure, the RNA–MP complex but not the remaining capsid shell enters the cell. MP also binds to its own PSs located toward either end of the MS2 genome. Recent asymmetric reconstruction of the MS2–pilus complex suggests that MP replaces a CP dimer of the C/C conformer in an otherwise entirely icosahedral protein shell, from which position it is ideally placed to contact the cellular receptor and escort the RNA into the cytoplasm. Note that the presence of the asymmetric MP component could not be detected in averaged X-ray and EM density maps. Once internalized, the MP is cleaved into two separate fragments by protease, allowing translation and replication to start. Temporal control of phage gene expression then regulates the production of progeny genomes and structural proteins that assemble prior to the action of the phage lysis protein. |
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Source | https://www.sciencedirect.com/science/article/pii/S0022283615006762?via%3Dihub#f0020 |
Author | Óttar Rolfsson, Stefani Middleton, Iain W. Manfield, Simon J. White, Baochang Fan, Robert Vaughan, Neil A. Ranson, Eric Dykeman, Reidun Twarock, James Ford, C. Cheng Kao, Peter G. Stockley |
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 05:53, 2 September 2020 | 512 × 410 (163 KB) | Guest2625 (talk | contribs) | Uploaded a work by Óttar Rolfsson, Stefani Middleton, Iain W. Manfield, Simon J. White, Baochang Fan, Robert Vaughan, Neil A. Ranson, Eric Dykeman, Reidun Twarock, James Ford, C. Cheng Kao, Peter G. Stockley from https://www.sciencedirect.com/science/article/pii/S0022283615006762?via%3Dihub#f0020 with UploadWizard |
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Orientation | Normal |
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Horizontal resolution | 300 dpi |
Vertical resolution | 300 dpi |
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29 January 2016
image/jpeg
a9cd96011adc5b249e420c96b81de92358faf7f2
167,179 byte
410 pixel
512 pixel
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