File:3puf rnaseH2 AGS mutations.png

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English: The human ribonuclease H2 complex. The catalytic subunit (RNASEH2A) is in light blue, the structural subunit RNASEH2B is in brown, and the structural subunit RNASEH2C is in pink. The position of the catalytic residues in the A subunit is indicated with magenta spheres. The positions of residues whose mutation is associated with Aicardi-Goutieres Syndrome are indicated in yellow, with the exception of the most common AGS mutation (A177T in the B subunit), which is shown with a green sphere.

Rendered from PDB 3PUF chains A, B, C, described in the paper:

The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutieres syndrome defects.

Figiel, M., Chon, H., Cerritelli, S.M., Cybulska, M., Crouch, R.J., Nowotny, M.

(2011) J.Biol.Chem. 286: 10540-10550

PubMed: 21177858 PubMedCentral: PMC3060507

DOI: 10.1074/jbc.M110.181974
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Author Opabinia regalis

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current03:06, 3 March 2017Thumbnail for version as of 03:06, 3 March 2017800 × 1,200 (422 KB)Opabinia regalis (talk | contribs){{Information |Description ={{en|1=The human ribonuclease H2 complex. The catalytic subunit (RNASEH2A) is in light blue, the structural subunit RNASEH2B is in brown, and the structural subunit RNASEH2C is in pink. The position of the catalytic resid...

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