File:AT-121 synthesis.svg

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English: Synthesis of AT-121, an opioid agonist, accoding to (2018). "A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates". Science Translational Medicine 10 (456): eaar3483. DOI:10.1126/scitranslmed.aar3483. PMID 30158150..
The synthesis of the first compound is described in (2008). "Synthesis and Pharmacological Evaluation of 1,2-Dihydrospiro[isoquinoline-4(3H),4′-piperidin]-3-ones as Nociceptin Receptor Agonists". Journal of Medicinal Chemistry 51 (4): 1058–1062. DOI:10.1021/jm7009606. PMID 18232652..
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