File:Antibodies-12-00025-g001-550.webp
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Antibodies-12-00025-g001-550.webp (550 × 336 pixels, file size: 18 KB, MIME type: image/webp)
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ANCA-Associated Vasculitis
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[edit]DescriptionAntibodies-12-00025-g001-550.webp |
English: Figure 1. Pathogenesis of AAV. Environmental factors induce neutrophils to express MPO and PR3 on their surface. These cells are then further activated and induce tissue damage through the production of reactive oxygen species (ROS) and the formation of neutrophil extracellular traps (NETs). Exposure of NETs, through a process termed NETosis, is associated with apoptosis of the neutrophils themselves, which release the antigens MPO and PR3 into the extracellular space. These proteins are processed by dendritic cells and then presented to T helper cells. The latter help the B cells to produce ANCA, which further activate the neutrophils thus maintaining the inflammatory process. |
Date | |
Source | https://www.mdpi.com/2073-4468/12/1/25 |
Author | Paroli, M.; Gioia, C.; Accapezzato, D |
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current | 23:57, 14 April 2024 | ![]() | 550 × 336 (18 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Paroli, M.; Gioia, C.; Accapezzato, D from https://www.mdpi.com/2073-4468/12/1/25 with UploadWizard |
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