File:Biocontainment by control over essential genes.jpg
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From the study "Safety by design: Biosafety and biosecurity in the age of synthetic genomics"
Summary
[edit]DescriptionBiocontainment by control over essential genes.jpg |
English: "Control can be attained by independent systems at different points along the flow of genetic information, allowing the free combination of different systems. (1) Recombinational switches lead to the excision of essential genes in restrictive conditions. (2) Transcriptional switches drive expression of essential proteins only if specific chemical inducers are available. (3) Post-translational switches direct essential proteins for degradation, leading to cell death unless a ligand is supplied. (4) Genetic code expansion can be leveraged to make cell survival dependent on the exogenous supply of a non-canonical amino acid." |
Date | |
Source | https://www.cell.com/iscience/fulltext/S2589-0042(23)00242-0 |
Author |
Authors of the study: Stefan A. Hoffmann James Diggans Douglas Densmore Junbiao Dai Tom Knight Emily Leproust Jef D. Boeke Nicole WheelerYizhi Cai |
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current | 16:08, 3 April 2023 | ![]() | 2,923 × 2,837 (548 KB) | Prototyperspective (talk | contribs) | Uploaded a work by Authors of the study: Stefan A. Hoffmann James Diggans Douglas Densmore Junbiao Dai Tom Knight Emily Leproust Jef D. Boeke Nicole Wheeler Yizhi Cai from https://www.cell.com/iscience/fulltext/S2589-0042(23)00242-0 with UploadWizard |
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