File:Development of diverse invasion modes from differentiated epithelium.jpg
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| Description | Figure 1: Development of diverse invasion modes from differentiated epithelium. Transition from the differentiated non-motile epithelium to a motile and invasive state is a gradual process during which cancer cells acquire diverse invasion modes. The non-motile state is represented by differentiated epithelial cells. Acquisition of an invasive phenotype is a result of a multistep process of cancer-associated EMT. Incomplete or partial EMT can induce collective migration in which cells can retain cell-cell adhesions and migrate collectively in a coordinated manner as sheets or cell clusters. Cells that undergo complete EMT often lose contact with the cell cohort or detach from the epithelial sheet, establish front-rear migratory polarity and migrate individually in the mesenchymal mode. Mesenchymally migrating cells may re-differentiate by mesenchymal-epithelial transition (MET) and re-establish an epithelium. Alternatively, by losing dependency on ECM and by increasing actomyosin contractility, mesenchymal cells can undergo mesenchymal-amoeboid transition (MAT) and invade in the amoeboid mode. The amoeboid phenotype could also be achieved by an increase in Rho activity in collectively migrating cells, which then undergo the collective-amoeboid transition (CAT); however, this is less frequent than MAT. The amoeboid and mesenchymal modes of invasion are often inter-convertible, and amoeboid cells can also revert to mesenchymal mode by amoeboid-mesenchymal transition (AMT). |
| Date | |
| Source | https://www.oncotarget.com/article/7214/text/ Cell polarity signaling in the plasticity of cancer cell invasiveness. Oncotarget. 2016; 7: 25022-25049. Retrieved from https://www.oncotarget.com/article/7214/text/ |
| Author | Gandalovičová A., Vomastek T., Rosel D., Brábek J. |
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| current | 14:39, 27 May 2024 | | 1,386 × 849 (473 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 1: Development of diverse invasion modes from differentiated epithelium. Transition from the differentiated non-motile epithelium to a motile and invasive state is a gradual process during which cancer cells acquire diverse invasion modes. The non-motile state is represented by differentiated epithelial cells. Acquisition of an invasive phenotype is a result of a multistep process of cancer-associated EMT. Incomplete or partial EMT can induce collective migra... |
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