File:Elife-24149-fig7-v2.jpg
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Summary[edit]
| Description |
English: SUR1 with a twisted ABC core conformation in saturating concentrations of GBC.
(A) Model of SUR1 with the various domains colored as in Figure 1, with each TM helix labeled. On the left, TMD1/NBD1 (green) is toward the front and TMD2/NBD2 (tan) is toward the back. (B) Cross-section of the SUR1 model, showing relative orientation of each of the 17 TM helices and a helix in L0. (C) Comparison of inward-facing ABC transporter structures: From left, C elegans Pgp (PDB code 4 F4C); mouse Pgp (4 M1M); hamSUR1. For each model, TMD2/NBD2 is colored tan. Lines on the side of the SUR1 NBDs denote the relative orientation of the NBD dimerization interface, demonstrating the observed twisting relative to other inward-facing structures. |
| Date | |
| Source |
eLife 2017;6:e24149 doi: 10.7554/eLife.24149 https://elifesciences.org/articles/24149 |
| Author | Gregory M Martin Craig Yoshioka Emily A Rex Jonathan F Fay Qing Xie Matthew R Whorton James Z Chen Show-Ling Shyng |
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