File:FcRn mechanism of inhibition-en.svg
Jump to navigation
Jump to search
Size of this PNG preview of this SVG file: 800 × 373 pixels. Other resolutions: 320 × 149 pixels | 640 × 299 pixels | 1,024 × 478 pixels | 1,280 × 597 pixels | 2,560 × 1,195 pixels | 1,140 × 532 pixels.
Original file (SVG file, nominally 1,140 × 532 pixels, file size: 109 KB)
Captions
Captions
Add a one-line explanation of what this file represents
Summary
[edit]| Description |
English: Simplified schematic illustration of the proposed mechanism of action of FcRn inhibitors, modified after D.D. Patel, J.B. Bussel: Neonatal Fc receptor in human immunity: Function and role in therapeutic intervention. Journal of Allergy and Clinical Immunology, 146(3), 2020, 467–478, doi:10.1016/j.jaci.2020.07.015. Left: IgG molecules enter cells by pinocytosis (1) and are taken up into endosomes containing neonatal Fc receptors (FcRn) (2). Because of the acidic pH in the endosomes, the FcRn binds tightly to the Fc portion of IgG. Sorting follows (3): unbound (excess) IgG is submitted to lysosomes (4) where it is degraded. Bound IgG molecules are retained (5) and transported out of the cell by exocytosis (6). In the physiological (near neutral) pH of the blood, the FcRn releases the IgG (7). Right: FcRn inhibitors bind to the FcRn with greater affinity than endogenous IgG and thus compete with endogenous IgG for FcRn binding. As a result, more endogenous IgG molecules are targeted to lysosomal degradation and fewer are recycled. |
| Date | |
| Source | Own work |
| Author | Benff |
| Other versions |
[]
|
Licensing
[edit]
I, the copyright holder of this work, hereby publish it under the following license:
This file is licensed under the Creative Commons Attribution-Share Alike 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- share alike – If you remix, transform, or build upon the material, you must distribute your contributions under the same or compatible license as the original.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 12:31, 19 January 2023 | | 1,140 × 532 (109 KB) | Polarlys (talk | contribs) | =={{int:filedesc}}== {{Information |description={{en|1=Simplified schematic illustration of the proposed mechanism of action of FcRn inhibitors, modified after D.D. Patel, J.B. Bussel: ''Neonatal Fc receptor in human immunity: Function and role in therapeutic intervention.'' Journal of Allergy and Clinical Immunology, 146(3), 2020, 467–478, doi:10.1016/j.jaci.2020.07.015.<br /> ''Left:'' IgG molecules enter cells by pinocytosis ('''1''') and are taken up into endosomes containing neonatal Fc... |
You cannot overwrite this file.
File usage on Commons
The following 3 pages use this file:
