File:GnRH Regulacion Pulsos.jpg

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Español: Figura 2 Ilustración esquemática del mecanismo hipotético que controla la generación de pulsos de la hormona liberadora de gonadotropina (GnRH) en mamíferos.

La neuroquinina B inicia y/o acelera la actividad neuronal KNDy sincronizada a través de receptores NK3 acoplados a Gq estimulantes para liberar kisspeptina que estimula la liberación de GnRH a través de GPR54 acoplado a Gq estimulante expresado en neuronas GnRH.

La dinorfina A es liberada de las neuronas KNDy luego termina la actividad neuronal KNDy a través de los receptores opioides κ inhibidores acoplados a Gi.
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Role of KNDy Neurons Expressing Kisspeptin, Neurokinin B, and Dynorphin A as a GnRH Pulse Generator Controlling Mammalian Reproduction. Front. Endocrinol. (2021) Review.

https://doi.org/10.3389/fendo.2021.724632
Author Uenoyama Y.; Nagae M..; Tsuchida H.; Inoue N.; Tsukamura H.

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