File:Host killing.png
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![File:Host killing.png](https://upload.wikimedia.org/wikipedia/commons/thumb/7/78/Host_killing.png/800px-Host_killing.png?20150418160921)
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[edit]DescriptionHost killing.png |
English: Some plasmids include a system which kills the cell in case it does not inherit a plasmid during cell division. These toxin-antitoxin systems consist of two or more closely linked genes that encode both a 'poison' and a corresponding 'antidote'. If the plasmid is absent after cell division, the unstable anti-toxin is degraded and the stable toxic protein kills the new cell. This is known as post-segregational killing (PSK).
An example is the CcdA/CcdB system which can be found on the F plasmid of Escherichia coli. CcdB targets the DNA gyrase and inhibits partitioning of the chromosomal DNA. As long as the cell contains the F plasmid, CcdB is bound and neutralized by CcdA. Upon loss of the plasmid, CcdA decays and the activity of CcdB kills the cell. |
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Source | Own work |
Author | Tobias Vornholt |
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current | 16:09, 18 April 2015 | ![]() | 5,391 × 3,568 (424 KB) | Tvornholt (talk | contribs) | User created page with UploadWizard |
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