File:Human embryo The molecular pathways involved in LEC differentiation from embryonic progenitors..jpg
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| Description | Figure 2. The molecular pathways involved in LEC differentiation from embryonic progenitors. (1) The mmp13b-par1-gnai2a axis activates VEGF-C/VEGFR3/ERK1/2 signaling through HHEX, which induces Prox1 expression and promotes the lymphangiogenesis; (2) Prox1, COUP-TFII, and SOX18 synchronously bind to the endogenous cyclin E1 promoter and interact with the differentiation and maintenance of LEC feature; (3) The expression of p53, p21, and p27 significantly promote the lymphatic sprouting in response to VEGF-C/VEGFR3 stimulation; (4) Dll4/NOTCH1/NOTCH4 axis regulates the expression of VEGFR3 via EphrinB2/Ras/MAPK signaling pathways; (5) The inhibitory splicing program Nova2 and effector Yap1, respectively, suppress or promote VEGFR3/ERK signaling pathway; (6) MAFB or Etv2 directly regulates the Prox1 and Flt4 expression; (7) miR-126a/Cxcl12a and VEGF-C/Flt4 signaling pathways cooperate and jointly direct LECs sprouting and extension. LEC: lymphatic endothelial cell. |
| Date | |
| Source | https://www.mdpi.com/cells/cells-11-04056/article_deploy/html/images/cells-11-04056-g002.png https://doi.org/10.3390/cells11244056 The Impact of Stem/Progenitor Cells on Lymphangiogenesis in Vascular Disease. Cells 2022, 11, 4056. |
| Author | Mou, R.; Chen, K.; Zhu, P.; Xu, Q.; Ma, L. |
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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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| current | 10:30, 26 April 2024 | | 2,211 × 1,888 (1.31 MB) | Rasbak (talk | contribs) | == {{int:filedesc}} == {{Information |description=Figure 2. The molecular pathways involved in LEC differentiation from embryonic progenitors. (1) The mmp13b-par1-gnai2a axis activates VEGF-C/VEGFR3/ERK1/2 signaling through HHEX, which induces Prox1 expression and promotes the lymphangiogenesis; (2) Prox1, COUP-TFII, and SOX18 synchronously bind to the endogenous cyclin E1 promoter and interact with the differentiation and maintenance of LEC feature; (3) The expression of p53, p21, and p27 si... |
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