File:Human embryo The molecular pathways responsible for LEC differentiation during adulthood stage.jpg
Jump to navigation
Jump to search
Size of this preview: 704 × 600 pixels. Other resolutions: 282 × 240 pixels | 563 × 480 pixels | 901 × 768 pixels | 1,202 × 1,024 pixels | 2,186 × 1,863 pixels.
Original file (2,186 × 1,863 pixels, file size: 1.2 MB, MIME type: image/jpeg)
Captions
Captions
Add a one-line explanation of what this file represents
Summary[edit]
| Description | Figure 3. The molecular pathways responsible for LEC differentiation during adulthood stage. (1) The inhibition of TGF-β1 and activation of VEGF-C promote Podoplanin and Prox1 expressions in different levels. (2) NF-κB, p50, and p65 regulate the transcription of VEGFR-3 in both LECs and macrophage-derived LECPs in a mouse peritonitis model. (3) LPS-activation of TLR4/NF-κB pathway influences the downstream targets of the VEGF-C/VEGFR3 pair, inducing myeloid cells to differentiate into M-LECP. (4) VEGF-C-treated adipose-tissue-derived stem cells were proved to promote lymphangiogenic function by regulating TGF-β/Smad signaling. (5) Similar with the embryonic stage, Dll4/NOTCH1/NOTCH4 axis regulates the expression of VEGFR3 via EphrinB2 /Ras/MAPK signaling pathway. (6) miR-129/HMGB1/AKT signaling in adipose-tissue-derived stem cells stimulates the lymphangiogenesis. LEC: lymphatic endothelial cell. |
| Date | |
| Source | https://www.mdpi.com/cells/cells-11-04056/article_deploy/html/images/cells-11-04056-g003.png https://doi.org/10.3390/cells11244056 The Impact of Stem/Progenitor Cells on Lymphangiogenesis in Vascular Disease. Cells 2022, 11, 4056. |
| Author | Mou, R.; Chen, K.; Zhu, P.; Xu, Q.; Ma, L. |
|
This file, which was originally posted to an external website, has not yet been reviewed by an administrator or reviewer to confirm that the above license is valid. See Category:License review needed for further instructions.
|
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Licensing[edit]
This file is licensed under the Creative Commons Attribution 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 14:07, 26 April 2024 | | 2,186 × 1,863 (1.2 MB) | Rasbak (talk | contribs) | {{Information |description=Figure 3. The molecular pathways responsible for LEC differentiation during adulthood stage. (1) The inhibition of TGF-β1 and activation of VEGF-C promote Podoplanin and Prox1 expressions in different levels. (2) NF-κB, p50, and p65 regulate the transcription of VEGFR-3 in both LECs and macrophage-derived LECPs in a mouse peritonitis model. (3) LPS-activation of TLR4/NF-κB pathway influences the downstream targets of the VEGF-C/VEGFR3 pair, inducing myeloid cells to... |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
