File:Hypothetical contribution of EMT-like process to the pathophysiology of RA.png
Jump to navigation
Jump to search
Size of this preview: 800 × 526 pixels. Other resolutions: 320 × 210 pixels | 640 × 421 pixels | 1,024 × 673 pixels | 1,280 × 841 pixels | 2,560 × 1,682 pixels | 3,240 × 2,129 pixels.
Original file (3,240 × 2,129 pixels, file size: 1.13 MB, MIME type: image/png)
Captions
Captions
Add a one-line explanation of what this file represents
Summary
[edit]
| Description | Figure 3. Hypothetical contribution of EMT-like process to the pathophysiology of RA (Rheumatoid Arthritis). Upon stimuli such as inflammation (IL-1β, TNF-α and IL-17) or hypoxia, several signaling pathways become activated in normal FLS present in the synovial lining. These EMT signaling pathways culminate with the production of several EMT-related TFs such as SNAI1, HIF-1α and Runx1 leading to the acquisition of more mesenchymal features. These activated FLS called RA-FLS gain migratory and invasive properties together with an increased resistance to apoptosis resulting in the generation of hyperplastic synovial lining. Abbreviations: AKT: protein kinase B; α-SMA: α-smooth muscle actin; CIA: collagen-induced arthritis; EMT: epithelial-mesenchymal transition; HIF1α: hypoxia-inducible factor 1α; IL: interleukin; MMPs: matrix metalloproteases; mTOR: mammalian target of rapamycin; NF-κB: nuclear factor-κB; PI3K: phosphoinositide 3-kinase; RA: rheumatoid arthritis; RA-FLSs: RA fibroblast-like synoviocytes; RUNX1: runt-related transcription factor 1; SMAD: homolog of the Drosophila protein, mothers against decapentaplegic (Mad) and the Caenorhabditis elegans protein Sma; SNAI1: Snail family transcriptional repressor 1; TFs: transcription factors; TGF-β: transforming growth factor-β; TNF: tumor necrosis factor. Created with Biorender.com (accessed on 20 August 2023). |
| Date | |
| Source | https://www.mdpi.com/1422-0067/24/19/14481 Involvement of Epithelial-Mesenchymal Transition (EMT) in Autoimmune Diseases. Int. J. Mol. Sci. 2023, 24, 14481. https://doi.org/10.3390/ijms241914481 |
| Author | Sarrand, J.; Soyfoo, M.S. |
|
This file, which was originally posted to an external website, has not yet been reviewed by an administrator or reviewer to confirm that the above license is valid. See Category:License review needed for further instructions.
|
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Licensing
[edit]
This file is licensed under the Creative Commons Attribution 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 00:39, 17 May 2024 | | 3,240 × 2,129 (1.13 MB) | Rasbak (talk | contribs) | {{Information |description=Figure 3. Hypothetical contribution of EMT-like process to the pathophysiology of RA (Rheumatoid Arthritis). Upon stimuli such as inflammation (IL-1β, TNF-α and IL-17) or hypoxia, several signaling pathways become activated in normal FLS present in the synovial lining. These EMT signaling pathways culminate with the production of several EMT-related TFs such as SNAI1, HIF-1α and Runx1 leading to the acquisition of more mesenchymal features. These activated FLS calle... |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
File usage on other wikis
The following other wikis use this file:
- Usage on nl.wikipedia.org
