File:Intracellular localization of polarity proteins during mesenchymal migration.jpg
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| Description | Figure 6: Intracellular localization of polarity proteins during mesenchymal migration. Polarity proteins localize to the leading edge, where they regulate Rho GTPases. At the leading edge, Cdc42 and Rac are activated, whereas the RhoA protein level is reduced as RhoA is degraded by Smurf. The Rho/ROCK pathway is stabilized at the cell rear by a positive feedback loop comprising lipid phosphatase PTEN and PIP2. In mesenchymal cells Par and Crumbs complexes co-localize with PIP3 (and PI3K) to the cell front, in contrast to epithelial cells, where the Par and Crumbs complexes co-distribute with PIP2 to the apical region. The Scribble complex, which is found basolaterally in epithelial cells, localizes to the leading edge, where it regulates Rho GTPases. Note that in mesenchymally migrating cells Rho could also be activated at the cell front |
| Date | |
| Source | https://www.oncotarget.com/article/7214/text/ Cell polarity signaling in the plasticity of cancer cell invasiveness. Oncotarget. 2016; 7: 25022-25049. Retrieved from https://www.oncotarget.com/article/7214/text/ |
| Author | Gandalovičová A., Vomastek T., Rosel D., Brábek J. |
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| current | 18:32, 27 May 2024 | | 1,326 × 774 (527 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 6: Intracellular localization of polarity proteins during mesenchymal migration. Polarity proteins localize to the leading edge, where they regulate Rho GTPases. At the leading edge, Cdc42 and Rac are activated, whereas the RhoA protein level is reduced as RhoA is degraded by Smurf. The Rho/ROCK pathway is stabilized at the cell rear by a positive feedback loop comprising lipid phosphatase PTEN and PIP2. In mesenchymal cells Par and Crumbs complexes co-locali... |
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