File:LH Pulsos Secrecion.jpg

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Español: FIGURA 1. Distintas poblaciones de neuronas kisspeptina en el hipotálamo.

Las neuronas RP3V KP inducen un aumento repentino de LH a través de la retroalimentación positiva mediada por estrógenos E2 y la ovulación que se muestra a la izquierda.

El receptor de estrógeno α (ERα) es responsable de mediar la retroalimentación negativa y positiva de E2. ERα puede señalar ya sea por translocación al núcleo y reclutamiento de cofactores al elemento de respuesta al estrógeno (ERE) (vía clásica), o por reclutamiento de otros factores de transcripción no a través de la ERE (en la vía "no clásica" ).
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Source Kisspeptin-neuron control of LH pulsatility and ovulation. Front Endocrinol (Lausanne). 2022; 13: 951938. doi: 10.3389/fendo.2022.951938
Author Harvey Stevenson, Samuel Bartram, Mikaela Maria Charalambides, Sruthi Murthy, Theo Petitt, Anjali Pradeep, Owen Vineall, Ikenna Abaraonye, Amelia Lancaster, Kanyada Koysombat, Bijal Patel, Ali Abbara

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