File:M awt315f4p.jpg
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M_awt315f4p.jpg (520 × 262 pixels, file size: 51 KB, MIME type: image/jpeg)
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DescriptionM awt315f4p.jpg |
English: Sural nerve pathology in patients with mutations in SLC52A2. Resin semi-thin sections, stained with methylene blue–azure A and basic fuchsine; ×63 magnification (A and C) and toluidine blue; ×40 magnification (F) and electron microscopy examination (B, D and E) of sural nerve fascicle cross sections in Patient E2 at 2 years of age (A and B), Patient E3 at 4 years of age (C and D), Patient E5 at 4 years of age (E), and Patient A3 at 3 years of age (F) demonstrate a loss of myelinated axons, preferentially of large diameters (8–12 µm). The endoneurium is fibrotic, and there are no inflammatory infiltrates. Numerous redundant Schwannian profiles (Bands of Büngner) are discernible ultrastructurally (B and D, arrows) consistent with the loss of myelinated fibres. Several myelinated fibres in the biopsy of Patient E5 (E) appear vacuolated and slightly enlarged—probably an artefactual change not to be confused with giant axons. Note the striking absence of regeneration clusters in all biopsies. Scale bars: B and D = 5 µm; E = 50 µm. |
Date | |
Source | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891447/ |
Author | A. Reghan Foley, Manoj P. Menezes, Amelie Pandraud, Michael A. Gonzalez, Ahmad Al-Odaib, Alexander J. Abrams, Kumiko Sugano, Atsushi Yonezawa, Adnan Y. Manzur, Joshua Burns, Imelda Hughes, B. Gary McCullagh, Heinz Jungbluth, Ming J. Lim, Jean-Pierre Lin, Andre Megarbane, J. Andoni Urtizberea, Ayaz H. Shah, Jayne Antony, Richard Webster, Alexander Broomfield, Joanne Ng, Ann A. Mathew, James J. O’Byrne, Eva Forman, Mariacristina Scoto, Manish Prasad, Katherine O’Brien, Simon Olpin, Marcus Oppenheim, Iain Hargreaves, John M. Land, Min X. Wang, Kevin Carpenter, Rita Horvath, Volker Straub, Monkol Lek, Wendy Gold, Michael O. Farrell, Sebastian Brandner, Rahul Phadke, Kazuo Matsubara, Michael L. McGarvey, Steven S. Scherer, Peter S. Baxter, Mary D. King, Peter Clayton, Shamima Rahman, Mary M. Reilly, Robert A. Ouvrier, John Christodoulou, Stephan Züchner, Francesco Muntoni, Henry Houlden |
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current | 22:53, 24 November 2023 | 520 × 262 (51 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by A. Reghan Foley, Manoj P. Menezes, Amelie Pandraud, Michael A. Gonzalez, Ahmad Al-Odaib, Alexander J. Abrams, Kumiko Sugano, Atsushi Yonezawa, Adnan Y. Manzur, Joshua Burns, Imelda Hughes, B. Gary McCullagh, Heinz Jungbluth, Ming J. Lim, Jean-Pierre Lin, Andre Megarbane, J. Andoni Urtizberea, Ayaz H. Shah, Jayne Antony, Richard Webster, Alexander Broomfield, Joanne Ng, Ann A. Mathew, James J. O’Byrne, Eva Forman, Mariacristina Scoto, Manish Prasad, Katherine O’Brien, Simon... |
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