File:Mechanism of action of mAb in the treatment of multiple sclerosis.webp

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English: Mechanism of action of mAb in the treatment of multiple sclerosis. Rituximab, ocrelizumab, ofatumumab, and ublituximab target CD20 expressing lymphocytes B causing ADCC and CDC of circulating lymphocytes B. Alemtuzumab targets CD52 expressing lymphocytes, eosinophils, monocytes/macrophages, and dendritic cells, resulting in their rapid depletion. Natalizumab binds to 4

1 integrin receptor on endothelial cells, preventing interaction between 4 1 integrin and VCAM-1 and, therefore, inhibiting migration of leukocytes through the BBB into the CNS parenchyma. Created with BioRender.com. ADCC antibody-dependent cell-mediated cytolysis, APC antigen-presenting cell, CD cluster of differentiation, CDC complement-dependent cytolysis, IL interleukin, TGF- 

transforming growth factor TNF- tumor necrosis factor
, VCAM-1 vascular cell adhesion molecule 1
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Source https://link.springer.com/article/10.1007/s13311-022-01224-9
Author Nik Krajnc, Gabriel Bsteh, Thomas Berger, Jan Mares & Hans-Peter Hartung

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current22:19, 21 June 2024Thumbnail for version as of 22:19, 21 June 2024685 × 671 (64 KB)Ozzie10aaaa (talk | contribs)Uploaded a work by Nik Krajnc, Gabriel Bsteh, Thomas Berger, Jan Mares & Hans-Peter Hartung from https://link.springer.com/article/10.1007/s13311-022-01224-9 with UploadWizard

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