File:Notch signaling in neural stem cells promotes cellcycle progression and inhibits neurogenesis in mouse embryo.png
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| Description | FIGURE 8 Notch signaling in neural stem cells promotes cell-cycle progression and inhibits neurogenesis. During the mammalian cell cycle, the length of time it takes cells to move through interphase (G1, S and G2) and, in particular, how long they spend in G1, helps determine their fate. Transition between stages of the cell cycle is driven by a series of cyclindependent kinases (Cdks) binding to specific cyclins to promote cell-cycle progression. Notch signaling increases the expression of both CyclinD and Cdk4/6, indirectly allowing cells to progress past the restriction checkpoint (R) and into S phase, promoting proliferation. Notch also inhibits the cell-cycle inhibitors p21 and p27, which further promotes proliferation and prevents the expression of genes involved in neurogenesis such as Nestin and Neurogenin1/2. |
| Date | |
| Source | https://www.researchgate.net/publication/334407321_Modeling_Mammalian_Commitment_to_the_Neural_Lineage_Using_Embryos_and_Embryonic_Stem_CellsModeling_Mammalian_Commitment_to_the_Neural_Lineage_Using_Embryos_and_Embryonic_Stem_Cells Modeling Mammalian Commitment to the Neural Lineage Using Embryos and Embryonic Stem Cells. July 2019. Frontiers in Physiology 10 DOI:10.3389/fphys.2019.00705 |
| Author | Rachel A. Shparberg, Hannah J. Glover, Michael B. Morris |
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Copyright © 2019 Shparberg, Glover and Morris. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 19:25, 30 April 2024 | | 1,176 × 798 (136 KB) | Rasbak (talk | contribs) | {{Information |description=FIGURE 8 | Notch signaling in neural stem cells promotes cell-cycle progression and inhibits neurogenesis. During the mammalian cell cycle, the length of time it takes cells to move through interphase (G1, S and G2) and, in particular, how long they spend in G1, helps determine their fate. Transition between stages of the cell cycle is driven by a series of cyclindependent kinases (Cdks) binding to specific cyclins to promote cell-cycle progression. Notch signaling... |
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