File:Pharmaceuticals-03-00725-g002-1024.webp
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DescriptionPharmaceuticals-03-00725-g002-1024.webp |
English: Figure 2. Theophylline directly activates histone deacetylases (HDACs) which deacetylate core histones that have been acetylated by the histone acetyltransferase (HAT) activity of co-activators, such as CREB-binding protein (CBP). This results in suppression of inflammatory genes and proteins, such as granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-8 (IL-8) that have been switched on by proinflammatory transcription factors, such as nuclear factor-κB (NF-κB). Corticosteroids also activate HDACs, but through a different mechanism resulting in the recruitment of HDACs to the activated transcriptional complex via activation of the glucocorticoid receptors (GR) which function as a molecular bridge. This predicts that theophylline and corticosteroids may have a synergistic effect in repressing inflammatory gene expression. |
Date | |
Source | https://www.mdpi.com/1424-8247/3/3/725 |
Author | Peter J. Barnes |
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current | 22:06, 8 January 2024 | 728 × 447 (133 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Peter J. Barnes from https://www.mdpi.com/1424-8247/3/3/725 with UploadWizard |
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