File:Receptor insulina dominios modelo.jpg

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Español: Figura 1. Reconstrucción del receptor de insulina (IR) en nanodiscos y ensayo de actividad.

A) Izquierda: dibujo esquemático que muestra el ectodominio (ECD), el dominio transmembrana (TMD) y el dominio tirosina quinasa (TKD).

Derecha: modelo estructural del IR humano de longitud completa (αβ)2 ensamblado a partir de estructuras cristalinas disponibles de la tirosina quinasa y el dominio extracelular, así como la resonancia magnética nuclear estructura de solución del dominio transmembrana.
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Source Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor. J Cell Biol (2018) 217 (5): 1643–1649 https://doi.org/10.1083/jcb.201711047
Author Theresia Gutmann , Kelly H. Kim. , Michal Grzybek , Thomas Walz , Ünal Coskun

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